Written by Ann Donahue, Carol Mendelsohn and series creator Anthony E. Zuiker and directed by Danny Cannon, the episode also served as a backdoor pilot episode of the spin-off series, CSI: Miami, set in Miami.
Former Las Vegas Police Chief of Detectives Duke Rittle is killed at a party and his daughter and wife are kidnapped.
While the team investigates both cases, police from Miami report sighting a little girl who fit the daughter's physical description.
Horatio finds the girl in a secluded plantation and the team discover some bullets, tire tracks and urine left behind by the kidnapper.
Horatio and Catherine then go a club called "Hive", where girls are wrapped in plastic and covered with honey.
Later, Eric finds more evidence from the bacteria in the swamp that ties Mrs. Rittle's killer to the same person who killed her husband and abducted her daughter.
They head to his latest client's place and find it bloodied and empty, the boat missing.
Horatio later talks to the young girl and tells her that he's lost someone, too; he also informs her that her aunt has flown to Miami.