It follows Nanaki Koga, a young man who wakes up from a two-year coma to learn that cross-dressing has become very popular among men while he was unconscious, and that the students and teachers in his all-male school now dress like women.

Shinagawa wrote the series with a focus on what he considered the major points of appeal in cross-dressing stories, including Nanaki's motivation for starting to wear women's clothes, how it turns habitual, and his behavior while dressed up.

[2][4] Crossdressing Pandemic was written and illustrated by Mikuzu Shinagawa, and was serialized by Kill Time Communication in Japanese in their digital magazine Comic Valkyrie from August 13, 2019[1][6] to July 12, 2021.

[2][10][11] In October 2020, versions of the opening chapters with added voice acting were released in the form of videos, in a collaboration with the VTuber agency Nijisanji: Nanaki was played by Yuki Chihiro, Ryou by Rindou Mikoto, Hikaru by Suzuki Masaru, and another cross-dressing character by Yuka Hiyamizu.

[13] Utako Suzuka of Nijisanji recommended the series for its characters and its combination of a pop art style and erotic elements, and said that it made her want to visit the manga's setting.