Cruz Diablo was filmed in the studios of the Compañía Nacional Productora, then located on Paseo de la Reforma,[2] during six weeks starting on September 13, 1934, at a cost of 200,000 pesos.
Editing was by Fernando de Fuentes, Fernando C. Tamayo and Harry Foster, musical direction by Max Urban, sound by Roberto Rodríguez and Joselito Rodríguez, set design by Jorge Fernández, photography by Alex Phillips, wardrobe by Vicente Tostado and A.X.
Peña, makeup by Tillie Orozco and weapons master Nicolás Reyero who was a general at the Military College and directed the instruction in the use of weapons such as the sword, foil and saber to actors Chato Ortín, René Cardona, Carlos López "Chaflán", Luis G. Ferreiro, Vicente Orona and Indio Fernández.
As part of the set design work, two production assistants contracted smallpox while handling antique clothing and period furniture, so the Ministry of Health declared the film studio quarantined.
[3] The film led to the founding of the production company Mex-Art (Impulsora Cinematográfica), owned by businessmen Pablo Bush and Alfonso Sánchez Tello.