The dorsum has uniform dark green dorsal background coloration interspersed with irregular-shaped large pale blue-grey lichenose blotches.

[5] The dermal chromatophore unit includes xanthophores, iridophores, and melanophores, which function together to display or inhibit certain coloring.

[5] The movement of melanosomes to melanophore fingers conceals the light-reflecting iridisphore layer, dictating a darker pigmentation at night.

Cruziohyla craspedopus is a high-canopy frog of primary tropical lowland rainforest at elevations of 50–600 m (160–1,970 ft) above sea level.

It only descends to lower branches for breeding, which takes place in fallen trees holding small water pools.