It was released as the album's first single on 7 October 2016 through Sony Music Latin.

This song has received much controversy over its lyrics as they arguably appear to suggest direct violence towards women.

[2] Despite this controversy, the popularity of "Cuatro Babys" has only risen with the song having gone quadruple Platinum.

The music video for "Cuatro Babys" premiered on 14 October 2016 on Maluma's Vevo account on YouTube.

The music video was directed by Jose Javy Ferrer and features Maluma, Noriel, Bryant Myers, and Juhn across multiple scenes surrounded by women who obey each of their commands.