[6] The city of Cuero got its start in the mid-19th century as a stopping point on the Chisholm Trail cattle route to Kansas.

According to the Handbook of Texas Online, "Gustav Schleicher founded the latter town as a way-station and moved to it soon afterward, in 1872.

The city had several Old West gunfights related to clan feuding following the Civil War.

Cuero's population grew considerably in the 1870s and 1880s, as residents from the coastal town of Indianola settled here after major hurricanes in this period destroyed sizeable portions of that city.

Cuero thrived through much of the late 19th and early 20th centuries by the introduction and practice of turkey ranching in the area.

Cuero is located east of the center of DeWitt County near the mouth of Sandies Creek, where it empties into the Guadalupe River.

[6] The climate in this area is characterized by hot, humid summers and generally mild to cool winters.

Cuero has an annual average precipitation of 38.0 in (965.2 mm), all rain, as snow is negligible in the area.

[8] As of the 2020 United States census, there were 8,128 people, 2,323 households, and 1,472 families residing in the city.

Turkey Fest is a local festival during which the townsfolk compete with people at various turkey-centric events.

In 1972, Charles Kuralt did an "On the Road" report for CBS News from Cuero, where he did his own turkey call.