Culberson is an unincorporated community in Cherokee County, North Carolina, United States.

Culberson is located on North Carolina Highway 60 near the Georgia state line, 10 miles (16 km) southwest of Murphy.

[2][3] Culberson is also home to a store, a few churches, a flea market, a local winery, several family-owned businesses, and a gas station on the NC/GA state line.

In 1817, early white farmers who wed Native Americans were granted property along the Nottley River.

The narrow-gauge line belonging to the Marietta and North Georgia Railroad operated up to six trains daily, with service to Knoxville and Atlanta.