Founded on 5 August 1923, it currently plays in Primera División RFEF – Group 1, holding home games at Estadio Reino de León, with a capacity of 13,346 seats.

In 1931, the club ceased activity and several teams were created in the city with the aim to replace them, but after the Spanish Civil War, Cultural Leonesa came back to the competition.

In 2011, the club was relegated to Tercera División due to unpaid debts to the players[3] and took two years to recover the place in the third tier.

On 3 January 2018, Leeds United announced an official partnership with Cultural Leonesa's owners Aspire Academy in Qatar.

[5] The link up saw Leeds players Yosuke Ideguchi and Ouasim Bouy both join Cultural Leonesa on loan as part of the unique partnership.

[9] On 2 December 2020, Cultural hired Iñigo Idiakez as Head Coach who came from Luton Town in EFL Championship and previously Leicester City and Derby County.