Cunninghame South was a constituency of the House of Commons of the Parliament of the United Kingdom (at Westminster) from 1983 until 2005.

The rest of the Cunninghame South constituency was merged with a northern area from Ayr and a small area from Carrick, Cumnock and Doon Valley to form Central Ayrshire.

The constituency was created to cover part of the Cunninghame district of the Strathclyde region, and it included the town of Irvine.

The rest of the district was covered by Cunninghame North.

In 1996 the Cunninghame district was reconstituted as the North Ayrshire council area, but the constituency boundaries remained unchanged until the seat disappeared in 2005.