Studies in Thailand researched the effects of crude extract from the root of Curcuma comosa on the uterus of the rat as compared to female estradiol hormone.

The extract was purified to its active ingredients and it was found that some diphenylheptanoid compounds, such as 1,7-diphenyl-3-acetoxy-hept-trans-6-ene, can inhibit the motility of the roundworm.

[3] Butanolic and ethyl acetate extract of rhizome of C. comosa had a stimulative effect on bile secretion and a decrease in blood cholesterol was reported.

[4] A 95% ethanol extract of C. comosa decreased uterine smooth muscle contraction in rats.

[5] An ethyl acetate extract of the rhizome was orally administered to male sheep and hamsters and a decrease in cholesterol and triglyceride were reported.