[1] The journal was established in 2017 as the first Gold Open Access journal of the American Society for Nutrition American Society for Nutrition.

[2] In 2018, Oxford University Press took over as publisher of the journal, although it is still owned by the American Society for Nutrition.

[4] It ranges from mechanistic studies at molecular, biochemical, and cellular levels to whole-body metabolism, clinical health, fitness, and population health.

The journal has six areas of emphasis, including Implementation Science; Research Methodology and Study Design Food and Nutrition Policy; Food & Nutrition of Indigenous Peoples; Brief Communications; and Food/Feed Composition, Nutritional Value & Toxicology.

The journal has published the abstracts of the ASN's annual meeting since 2018.