Larry meets someone he believes to be a woman, but is actually a transvestite, who turns him into a "queerwolf" by biting him on the buttocks.

People hunting the werewolf discover the transvestite at Larry's apartment, and they also warn him about a curse.

[3] Author David Bleiler wrote in his book TLA Video & DVD Guide 2005 that "while offensive to some, [the film] is more harmless camp than incendiary hatred".

[4] A Rovi review said, "Tasteless and raunchy, the film will offend many, but those looking for a sick, offbeat comedy will enjoy Pirro's irreverence.

"[3] Adam Tyner, writing for DVD Talk, said, "Anyway, even though I do see Curse of the Queerwolf as superior in a number of ways, for whatever reason, I didn't find it particularly funny.