Lofton was selected by the Atlanta Falcons in the second round of the 2008 NFL draft.

Curtis was coached during high school, including his junior year where he led Kingfisher to its first state championship, by Rick Vancleave, Stan Blundell, Mark Redwine, Larry Hart, and Doug Jech.

Lofton was a Parade first-team All-American (2004), The Oklahoman All-State (2004), first-team coaches All-state 2004 and also nominated for the March of Dimes Oklahoma Headliners Banquet as one of the top scholar-athletes in the state of Oklahoma.

Lofton saw spot duty at middle linebacker, but got most of his action on the Sooners' special teams.

Lofton earned first-team All-American honors from The NFL Draft Report, Football Writers Association of America, Sports Illustrated and The Sporting News adding second-team accolades from the Associated Press.

In the 2007 Big 12 Championship Game, Lofton picked off a Chase Daniel pass and returned it 26 yards to the Tiger 7-yard line.

Lofton announced on January 14, 2008 that he would forgo his senior season and enter the 2008 NFL draft.

[4] Lofton became a starter in his rookie 2008 season and ranked fourth on the team with 94 tackles (67 solo).

[10] The article, "Just a Kid from Kingfisher: The Story of Curtis Lofton," was written by his lifelong friend, Adam Arms.