He was selected to the 2015 Pro Football Writers Association (PFWA) NFL All-Rookie Team at three positions.

He helped lead the Booker T. Washington Hornets to Oklahoma Secondary School Activities Association (OSSAA) championships in both football and basketball.

As a sophomore, he made several notable contributions to the team on its way to the school's first football OSSAA championship in 24 years.

[7] Booker T. Washington compiled a 13–1 record and won the 2010 OSSAA 5A championship in football his senior year.

[24] Things started to turn around on October 15 when he posted a 100-yard return of a kickoff for a touchdown against Texas Tech.

His first Player of the Week recognition came on October 24 after he produced a 251-yard all-purpose yards performance on October 22 against Kansas in the Governor's Cup that included a 97-yard kickoff return touchdown while becoming the first player in school history to return kickoffs for touchdowns in consecutive games and having a career-high five-reception, 110-yard receiving day.

[28][29][30] Due to what was at first an undisclosed injury,[31] he did not play in the final three games of Kansas State's regular season.

[39][40][41][42][43] Lockett failed to play in 75 percent of the Wildcats' games to be eligible to be the NCAA statistical leader for average kickoff return yardage.

[57] Prior to the 2013 season, Lockett was recognized as a 2013 Allstate/American Football Coaches Association (AFCA) Good Works Team nominee.

[58] He opened the season with 7 receptions for 113 yards, including a 56-yard touchdown pass, against North Dakota State on August 30.

[63][64] This receiving yardage total was the 2nd highest in the first four weeks of the season behind Texas A&M wideout Mike Evans' 297 yards.

[66] He returned to the lineup on October 26, to post three touchdowns and 111 yards on 8 receptions and help Kansas State achieve its first Big 12 win of the season against West Virginia.

[70][71] Lockett was named the Big 12 Conference Special Teams Player of the Week on November 25 upon becoming the all-time Kansas state leader in career kickoff return yards with 1,780.

[72][73] Following the season, he was recognized as an All-Big 12 Conference first team selection as both a wide receiver and an all-purpose player.

[75][76] In the December 28, 2013 Buffalo Wild Wings Bowl, Lockett had 10 receptions for 116 yards and 3 touchdowns against Michigan.

With just a bowl game remaining, Lockett's career total of 3,546 receiving yards ranked sixth in Big 12 Conference history.

[115] He was a second team selection by USA Today at wide receiver,[116] Walter Camp Foundation at return specialist,[117] and AP as an all-purpose player.

[126] Lockett's senior season totals led the Big 12 Conference in receiving yards and the nation in punt return average.

[140] His performance for the first three weeks of the season earned him recognition as National Football Conference (NFC) Special Teams Player of the Month for September 2015.

[142] Lockett posted his first career touchdown reception on Thursday Night Football against the San Francisco 49ers on October 22, 2015.

Lockett was one of only three rookies to be selected to the Pro Bowl, along with Rams running back Todd Gurley and Chiefs cornerback Marcus Peters.

[149] In the final week of the season on January 3 against the Arizona Cardinals, Lockett set up several scores by the Seahawks with long punt returns and receptions.

[152] For his performance over the last 5 weeks of the season in which he amassed 759 all-purpose yards, he earned the NFC's Special Teams Player of the Month for December/January, making him the second rookie to win the award twice (Tamarick Vanover, 1995).

[155] He was also voted along with teammate Thomas Rawls to be in the Pro Football Writers Association NFL All-Rookie Team (2015).

[168] In the Wild Card Round of the 2018–19 NFL playoffs against the Dallas Cowboys, Lockett had four catches for 120 yards in the 24–22 loss.

[170] In Week 1 against the Cincinnati Bengals, Lockett only caught one pass in the game; however, it was for 44 yards and a fourth quarter touchdown in the 21–20 win.

[172] In Week 5 against the rival Los Angeles Rams, Lockett caught four passes for 51 yards and a toe-tapping touchdown catch in the back of the endzone in the 30–29 win.

[173] In Week 9 against the Tampa Bay Buccaneers, Lockett caught 13 passes for 152 yards and two touchdowns in the 40–34 overtime win.

[180] During Sunday Night Football against the Cardinals in Week 7, Lockett finished with a career high of 15 receptions for 200 receiving yards and three touchdowns.

[195] In Week 2, Lockett recorded two touchdowns, including the game-winning score, during a 37–31 overtime victory over the Detroit Lions.