Samuel attended Erasmus Hall High School in Brooklyn, New York, where he played as a running back for the Dutchmen football team and also ran track.

[2] A 4-star running-back recruit, Samuel committed to play college football for the Ohio State Buckeyes.

Samuel is the only player in Ohio State history to ever gain over 1,000 career yards in both rushing and receiving.

[22] In Week 11 against the Detroit Lions, Samuel recorded 8 catches for 70 yards, including the first touchdown pass thrown by quarterback P. J. Walker during the 20–0 win.

[25] In Week 17 against the New Orleans Saints, Samuel recorded seven catches for a season high 118 yards during the 33–7 loss.

[27] Samuel signed a three-year, $34.5 million contract with the Washington Football Team on March 18, 2021.

[33] Samuel tweaked his groin in practice just days before the opening game of the season and was placed on injured reserve.

[37] Samuel played in the entirety of the 17 game season and was occasionally used as a running back as well as a wide receiver.

[41] Samuel made his postseason debut in the Wild Card round game versus Denver.

He scored his first career postseason touchdown on a 55-yard reception from Josh Allen in the fourth quarter of a 31–7 victory.