[6][7][8][9] Cram's first foray into the world of theater came at age six when she played the role of Moth in a production of A Midsummer Night's Dream at the Alabama Shakespeare Festival.

[14] The Arthur spinoff Postcards from Buster was subject to a controversy that eventually involved United States Secretary of Education Margaret Spellings after an episode depicted a Vermont family with two lesbian mothers.

[14] Cram's Off-Broadway debut also came in 2009 when her play A Lifetime Burning, based on the experiences of author Margaret Seltzer and the discovery of her partially fictitious memoir Love and Consequences, was produced at 59E59 Theaters by Primary Stages.

[13] Aside from Arthur, Cram has also written for the Cbeebies children's television series The Octonauts,[15] and contributed two episodes to the Showtime comedy-drama The Big C.[16] As of January 2014, she teaches playwriting as part of the joint Fordham University – Primary Stages Master of Fine Arts program.

[17] Based on the children's book of the same name by Don Freeman Previewed beginning June 30 Produced by LAByrinth Theater Company Additionally, Cram's one-act West of Stupid was anthologized in The Best American Short Plays 2000-2001.