It follows the eponymous leather-clad genetic engineering survivor who cross-dresses (to conceal her identity) working as a male teacher during the day, and fights against the scientist who created her at night.

Cybersix defeats von Reichter's creations, the human-like Techno series and the more Frankenstein's monster-like Fixed Ideas, in order to drink the sustenance liquid contained within them.

Along the way, she meets an orphaned boy Julian, Reichter's cloned son José, and high school teacher Lucas Amato.

Parts of the material were translated in Spanish and published in Argentina (since 1993 by El Globo Editor) and in Spain (since 1995 by Planeta De Agostini).

[8] In a 2007 interview, Trillo stated that he and Meglia dropped the lawsuit due to lack of financial resources, although the issue is still a matter of controversy.