The main city of Kybistra/Ḫubišna was located at the site corresponding to present-day Karahöyük [tr],[2] about 10km northeast of the modern town of Ereğli in Konya Province, Turkey.

[8][1] Prior to the Hittite period, Hubisna was a stregic hub guarding the northern end of the Cilician Gates going south to Tarsus.

According to the Telepinu Proclamation, Ḫubišna was one of the places which the 17th century BCE founder-king of the Hittite Old Kingdom, Labarna I had conquered and over which he had subsequently appointed his sons as rulers.

[2] Ḫubišna was mentioned in the texts of the Hittite Empire, as a country located in southern Anatolia, in the part of the Lower Land corresponding to the later Classical Tyanitis.

Esarhaddon appears to have reached Ḫubišna by passing through the Göksu river valley and bypassing the Anti-Taurus Mountains and Tabal proper.

William Martin Leake observed, "We learn also from the Table that Cybistra was on the road from Tyana to Mazaca, and sixty-four Roman miles from the former."

Cyrus took part in the Council of Chalcedon in 351 and was a signatory of the letter that the bishops of the Roman province of Cappadocia Secunda, to which Cybistra belonged, sent in 458 to Byzantine Emperor Leo I the Thracian after the murder of Proterius of Alexandria.