[7] Cyrille grew up in Harlesden, located in the Borough of Brent, and attended Cardinal Hinsley High School.

"[8] After leaving school, Regis trained as an electrician, earning a City and Guilds diploma; he continued to practise the trade until his move into professional football.

[10] Regis was spotted by West Bromwich Albion's chief scout Ronnie Allen, who recommended that the First Division club should sign him.

[11] With the Albion directors unsure of paying a four-figure fee for such a young, unproven player, Allen offered to fund any initial payment from his own pocket, so sure was he that Regis would make it in the top tier of English football.

[12] Shortly after bringing Regis to Albion, Allen took over as team manager, following the resignation of his predecessor Johnny Giles.

Regis made his first team debut in a League Cup match against Rotherham United on 31 August 1977, scoring twice in a 4–0 win.

Before the 1991–92 season, Regis joined Aston Villa on a free transfer, reuniting him with his former manager at West Brom, Ron Atkinson.

[21] He was one of six Villa players who made their debut for the club on the opening day of the season, scoring in a 3–2 win away to Sheffield Wednesday.

[21] Regis made over 40 appearances in his first season for Villa, and finished as the club's leading league goalscorer, joint with Dwight Yorke.

[3] The result helped England reach the latter stages of the 1980 European Championship, although it was the only one out of six qualifying matches in which Regis participated.

[29] His final international appearance for England was in 1987 against Turkey at Wembley, which ended in an 8–0 win for the home side, where he came on for the last 20 minutes.

[40] Regis became an evangelical Christian after a car crash claimed the life of his friend and former teammate Laurie Cunningham in 1989.

[42] After retiring from playing, Regis worked in a variety of coaching roles before becoming an accredited football agent with the Stellar Group Ltd.

Regis and his wife Julia visited water-related projects in Ethiopia in 2007, as part of their continued support for WaterAid.