[2] In 1890, the family moved to Noel, Missouri, where Cyrus received a certificate to teach in public schools.

He bought a farm near Tulsa in 1908, where he raised Holstein and Ayshire cattle, Druoc hogs, Shopshire sheep, and Percheron horses.

In the following year, he established a 1,400 acres (570 ha) farm northeast of Tulsa for diversified agriculture.

He eventually became involved in the creation of the Ozarks Trails, a system of roads connecting St. Louis and Amarillo, Texas.

Avery successfully argued that to avoid the high peaks of the Rocky Mountains, the road should turn south through Tulsa and Oklahoma City, continue west across the Texas Panhandle, New Mexico, Arizona, and southern California.

His suggestion that this highway should go east from Springfield to St. Louis and Chicago, Illinois, as commerce naturally continued in that direction, was also adopted.

They countered Avery's US route by pushing for US 60 to run between Virginia Beach and Los Angeles; the Springfield to Chicago section could be "U.S. 60 North".

Kentucky threatened to walk completely out of the new highway system (individual states could not be forced to participate in it).

[1] Cyrus Avery died in Los Angeles, California on July 2, 1963,[1][2] and was buried in Rose Hill Cemetery in Tulsa.

[1] In late 2012, artist Robert Summers unveiled East Meets West, a sculpture in Cyrus Avery Centennial Plaza at Southwest Boulevard at Riverside Drive in Tulsa.

[11] The detailed 135%-scale bronze depicts Avery stopping his Ford on the 11th Street Bridge as the vehicle frightened two horses pulling a wagon laden with oil barrels.