[2] Studies done with cytochalasin D (CD) have found that CD-actin dimers contain ATP-bound actin upon formation.
[2] CD is very effective; only low concentrations (0.2 μM) are needed to prevent membrane ruffling and disrupt treadmilling.
[7] The effects of many different cytochalasins on actin filaments were analyzed and higher concentrations (2-20 μM) of CD were found to be needed to remove stress fibers.
Due to their chemical nature, cytochalasins can help researchers understand the importance of actin in various biological processes.
[9] In vitro and clinical data indicate that the clot strength in FIBTEM increases in a fibrinogen concentration-dependent manner independent of platelet count.