[10] In 1830, Samuel Lover was secretary of the Royal Hibernian Academy and lived at number 9 D'Olier Street.

In 1891 James Franklin Fuller designed the D'Olier Chambers building of yellow brick and terracotta for the Gallaher Tobacco Company.

[16] The Dublin central clinic of the Irish Blood Transfusion Service is based on the 2nd Floor of LaFayette House on the street.

[12] In 2014 the IBTS considered moving to a cheaper city centre location due to high running costs,[18] but remain on D'Olier Street as of May 2022.

[12] Developed in the 1890s for the Liverpool and Lancashire Insurance Company and designed by architect John Joseph O'Callaghan, it was described as a "Portland stone baronial exercise with Gothic and Ruskinian leanings.