By that time, Debowiec had already been a local center of administration, as first mention of a Roman Catholic parish of St. Bartholomew existing here dates back to 1328.

By early 15th century, Debowiec had a number of artisans, and among its most famous owners was knight Marcin of Wrocimowice, who resided here in 1433–1442.

His son, Marcin of Debowiec was captured by Turks during the Battle of Varna, and spent 20 years in Turkish captivity.

Even though the town and its castle burned in 1512, it was quickly rebuilt, and became a local trade center, with a brewery, wine cellars, tax office, watermill and other businesses.

In 1624, Debowiec was once again raided by Crimean Tatars, and on April 1, 1626, almost whole town burned in a great fire, after which only parish church and seven houses stood.

Local peasants actively participated in the so-called Galician slaughter (1846), while 26 patriots from Debowiec fought in the January Uprising.

Due to widespread poverty, a number of local residents left Debowiec and adjacent villages in the late 19th and early 20th century, emigrating either to the United States or Brazil.