Krajczy koronny in 1574, castellan of Radom in 1583, voivode of Sandomierz Voivodship in 1590, żupnik ruski, starost of Lwów in 1593, starost of Sambor, Sokal, Sanok, Rohatyn.

His daughter Urszula Mniszech, born in 1603, married prince Konstanty Wiśniowiecki, voivode of Russia (1564–1641).

Anna Mniszech married Piotr Szyszkowski, castellan of Wojno.

Franciszek Bernard Mniszech became castellan sądecki in 1638, starost sanocki i szczyrzycki, married Barbara Stadnicka.

Jerzy Mniszech is one of the personas on the painting by Jan Matejko: Kazanie Skargi (The Sermon of Piotr Skarga).