Holtom gained an AB from Kalamazoo College in 1907, a BD from Newton Theological Seminary and a PhD in History from the University of Chicago.
He was sent to Japan by the American Baptist Foreign Mission Society and was Professor of Modern Languages at Tokyo Gakuin during 1914–1915.
The Professor of Shinto at Tokyo Imperial University, Katō Genchi (加藤玄智), praised it as "a fine piece of work with the right man in the right place...[it] makes good use of the expositions of our historians and thereby avoids falling into conjecture; at the same time out of his own original study he advances new interpretations".
[2] Robert S. Ellwood in 1969 said Holtom's study of Shinto (The National Faith of Japan) "is undoubtedly still the best general study, but its prewar provenance leaves it now rather dated, and there is not enough depth of material on rite and symbol to satisfy a history of religions approach".
[3] Douglas G. Haring stated that Holtom was: ...the foremost American student of Shinto...[his] meticulous studies of Japanese folk religion belong among the classics of anthropological research.