He played college football for the Vanderbilt Commodores and was selected 119th overall in the fourth round of the 2009 NFL draft by the Chicago Bears.

While playing at Vanderbilt, he garnered First-team All-SEC honors from the Associated Press in his sophomore and junior years.

[9] During the 2010 season, Moore saw considerable playing time contributing as the nickelback when the team left its base 4–3 coverage.

On October 24, 2010, he intercepted a pass from Donovan McNabb of the Washington Redskins and ran it back 54 yards for a touchdown.

[14] On February 14, 2014, the Tampa Bay Buccaneers signed Moore, reuniting him with his former coach in Chicago, Lovie Smith.