The D46 state road starts in the Osijek-Baranja County in the region of Slavonia, enters the Vukovar-Syrmia County and intersects it orthogonally to the D55 state road, ending in the region of Syrmia.

Following the Tovarnik border crossing it continues in Serbia as the State Road 120.

As with all other state roads in Croatia, the D46 is managed and maintained by Hrvatske ceste, state-owned company.

[2] Traffic is regularly counted and reported by Hrvatske ceste, operator of the road.

[3] In early 2019 villages of Tovarnik, Ilača and Banovci organized joint demonstrations against truck drivers from countries other than Croatia and Serbia which are causing heavy traffic congestion on the D46 road while waiting to cross the state border between Croatia and Serbia.