See the Organisation for Economic Co-operation and Development (OECD) report, below, for a description of the method.
Toxicants, after they have been taken up by the organism and reached the target site, are assumed to affect one or more metabolic processes as specified in DEB theory.
A change in a single metabolic process has particular consequences for both growth and reproduction of the organism.
Therefore, the specific pattern of growth and reproduction over time provides information about the affected process.
A key concept in this method is the determination of the No Effect Concentration.