Originally a Miami-based radio personality, Khaled has since become known for enlisting high-profile music industry artists to perform on singles and albums, for which he often serves as producer and hype man.

Known as the "Anthem King", his distinctions are his booming voice presence, "motivational" abstractions, maximalist production style and numerous catchphrases.

His two subsequent releases—We Global (2008) and Victory (2010)—both peaked within the top ten of the Billboard 200; the latter was supported by the single "All I Do Is Win" (featuring T-Pain, Ludacris, Snoop Dogg and Rick Ross), which received triple platinum certification by the Recording Industry Association of America (RIAA).

His fifth studio album and major label debut, We the Best Forever (2011), saw continued commercial success and brought Khaled to mainstream prominence by spawning his first Billboard Hot 100-top ten single, "I'm on One" (featuring Drake, Rick Ross and Lil Wayne).

His record label, We the Best Music Group has distributed his releases since its formation in 2008, though Khaled signed other artists to the imprint including Ace Hood, Kent Jones, Mavado, Flipp Dinero, and Vado, among others.

[10][11][12] During his early career, Khaled became acquainted with several young artists and helped them before their breakthrough; these include Birdman, Lil Wayne, and Mavado.

[18] Khaled made a guest appearance on Birdman's 2007 album 5 * Stunna on the single "100 Million", which also features Rick Ross, Dre, Young Jeezy and Lil Wayne.

[19] In 2008, Khaled's third album We Global came out with singles "Out Here Grindin" (with Akon, Rick Ross, Lil' Boosie, Trick Daddy, Ace Hood, and Plies) followed by "Go Hard" (featuring Kanye West and T-Pain).

The album featured guest appearances from Drake, Lil Wayne, Rick Ross, Nas, Snoop Dogg, Ludacris, Nelly, and more.

[24] On August 19, Khaled signed to Cash Money Records along to Universal Motown, the album will be released under the label, also under E1 Entertainment, Terror Squad, Def Jam South, and Khaled's own label We the Best Music Group, with confirmed guests as Fat Joe, Chris Brown, Keyshia Cole, Cee Lo Green, Cool & Dre, Rick Ross, Kanye West, Jay-Z, Nas, Birdman, Lil Wayne, T.I., Akon, Drake, and Nicki Minaj[25][26][27][28] The first single, "Welcome to My Hood", featuring Rick Ross, Plies, Lil Wayne and T-Pain was released on January 13, 2011; it was produced by the Renegades, and co-produced by DJ Khaled himself along with the Nasty Beatmakers.

[31] On December 10, 2011, DJ Khaled announced the title of his next album, Kiss the Ring in an online video, with the release date as "coming soon" in 2012.

[32] Guests on the album include T-Pain, French Montana, Future, Wiz Khalifa, Nas, Plies, Ace Hood, Kanye West, Rick Ross, Meek Mill, Big Sean, 2 Chainz, Jadakiss, Kirko Bangz, Mack Maine, Tyga, T.I., J. Cole, Kendrick Lamar, Big K.R.I.T., Mavado, and Wale.

After attending a doctor due to a bald spot on his beard, Khaled was told that he was "suffering from success", which inspired the album's title.

"[43] The same day, Flex premiered Khaled's new single, "I Wanna Be with You", which featured Minaj, as well as frequent collaborators Future and Rick Ross.

The interview was noted due to Khaled "cursing, gesturing, and tossing the microphone to the floor in an effort to convey the importance and impact of the music he has coming this summer.

"[46] A few hours after that, he released the single called "They Don't Love You No More", also featuring frequent collaborators Rick Ross, Meek Mill and French Montana.

[49] On July 1, 2014, Khaled announced that he has partnered with Danish audio company Bang & Olufsen to launch his own brand of headphones, titled "We the Best Sound".

"[52] On the same day, DJ Khaled released the third single off the album I Changed a Lot titled "How Many Times", featuring Chris Brown, Lil Wayne and Big Sean produced Bkorn, Lee on the Beats and OZ.

[56] On February 29, 2016, Khaled signed a management-only deal with Jay Z's company, Roc Nation and announced his ninth studio album, Major Key, was going to be released in 2016, specifically on July 29, and has a lion on the cover.

[59] He announced his album would feature Jay Z, Future, Kanye West, Big Sean, Lil Wayne, and Rick Ross.

[58][59] In late 2015 to early 2016, a number of Snapchat videos of Khaled's detailing his "key to success" received significant attention on the internet due to his larger-than-life persona.

He released several music videos for the album's singles on that day through May 20, including one for "Higher", featuring late rapper Nipsey Hussle and John Legend, a track which also garnered Khaled his first Grammy Award.

The announcement was accompanied with a video trailer documenting his life and career, including the birth of his sons Asahd and Aalam, who both would executive produce the album, and winning his first Grammy Award.

[82][83] In April 2014, Ross featured on the song "They Don't Love You No More", the first single from Khaled's eighth studio album I Changed a Lot.

In 2016, Ross featured on two songs from Khaled's ninth studio album, Major Key: the single “Do You Mind” and the track "Fuck Up the Club".

When he's trying to muster up the right word, either for clarity or comedic timing, his eyes carry a piercing seriousness, like an athlete laser-focused on a play.

[87] In January 2017, Khaled purchased Robbie Williams's former house in Mulholland Estates, a gated community in Los Angeles, California.

[91][92] In 2016, he wrote a book, The Keys: A memoir, which includes his opinions on success, recounts life stories, and describes contributions from other musicians.

[80] In November 2018, together with Floyd Mayweather Jr., Khaled agreed to a total settlement of $750,000 with the Securities and Exchange Commission (SEC) for failing to disclose payments accepted from issuers of an initial coin offering, specifying a personal $50,000 promotional payment from beleaguered cryptocurrency firm Centra Tech Inc.,[97] whose co-founders were indicted for fraud in May 2018.

According to the SEC, "they are its first cases involving charges for violating rules on touting investments in so-called initial coin offerings, or ICOs.