Isaiah Major[1] was born in Chicago, Illinois, United States, growing up on the south side of the city and DJing from an early age.

[citation needed] In the growing House scene of Chicago, DJ Rush quickly rose to prominence in the electronic music genre.

He made his first appearances as a DJ in the Chicago clubs Music Box, the Powerhouse and the Warehouse where he played his sets for up to ten hours.

[5] In 2001 he displaced Jeff Mills as the Reader's Choice for most popular DJ in Groove-Magazine (a German magazine for electronic music released since 1989).

DJ Rush is known for his unique sense of style- being 6' 6" (1.98 m) tall and often performing in platforms and extravagant costumes, citing Grace Jones and Missy Elliott amongst his inspirations.