[5][6][7] The product of this gene is one of the membrane-associated guanylate kinases localized at postsynaptic density in neuronal cells.

This protein may play a role in the molecular organization of synapses and in neuronal cell signaling.

Alternatively spliced transcript variants encoding different isoforms have been identified, but their full-length nature is not known.

[7] DLGAP2 has been shown to interact with DLG4, the canonical synapse marker protein, which in turn binds to N-Methyl-d-aspartate (NMDA) receptors and Shaker-type K+ channels.

[8] As with many other synaptic genes, including its binding partner Shank2, DLGAP2 has been shown to be associated with Autism.