It is located along Eulogio Rodriguez Senior Boulevard, in Quezon City, Philippines.

The De Los Santos College was established and recognized by DECS (Dept.

It was founded by Dr. Jose V. De Los Santos, founder of Philippine Orthopedics in 1975.

Applications were limited and only those high school graduating students with a minimum rating of 95% in their NCEE (National College Entrance Examination) were accepted into the College of Nursing to increase the quality of the institution.

The merger produced DLS-STI College of Health Professions Inc.[1] In October 2013, STI Health Professionals, purchased 100 percent of Makati Medical Center College Inc. from Medical Doctors Inc., a subsidiary of the Metro Pacific Investments Corporation, through its sister company PWU.