They compete at the University Athletic Association of the Philippines (UAAP), as well as at the PFF Women's League (PFFWL), the top flight domestic women's football league in the Philippines.

They hold the record of having the longest championship streak, winning four straight titles from UAAP Season 65 to 68 (2002–2005).

[3][4] The collegiate squad was among the pioneer teams of the first season of the PFF Women's League which ran from 2016 to 2017.

De La Salle was assured of the league title of the 2016–17 season after their first second round match against OutKast which ended in a 3–0 win.

[7] The Lady Booters also won the third league title in 2020 against UST, completing their third consecutive championship.