The DLSU Lady Spikers are hailed as the most dominant women's volleyball team in the UAAP for the last two decades (and Final Four era) having won 12 championships, eight silver and two bronze finishes.

Graduating team captain Charleen Cruz was hailed the Most Valuable player of the Finals for the second straight year (Season 73 and 74).

[10] In 2012–2013, after an opening day loss to the UST Golden Tigresses, the Lady Spikers won the rest of their elimination round games to finish with a 13–1 win-loss card.

The UAAP Season 76 women's volleyball finals series is notable for being the longest championship series in the league's history (lasting 5 games after the Ateneo Lady Eagles overcame La Salle's thrice-to-beat advantage in the 5-set thriller Game 3), with La Salle being the first ever UAAP varsity team to gain an automatic finals berth as top seed but losing to a lower-seed team in the championship series in the 2008 to the present form of the UAAP's Final Four playoffs format era.

[15] DLSU then got the number 2 spot entering the Final Four with a twice-to-beat-advantage, but lost to the FEU Lady Tamaraws in game 1 (a 5-set thriller).

[17] In Game 3, the Lady Spikers, powered by Best Setter Kim Fajardo together with graduating seniors Ara Galang, Mika Reyes, Cyd Demecillo, Mika Esperanza and Carol Cerveza, and juniors Kim Kianna Dy, best blocker Majoy Baron and best digger and best receiver Dawn Macandili, dethroned the Ateneo Lady Eagles, 3 sets to 1, to win their ninth UAAP championship.

[30][31] In 2024, the Lady Spikers bannered by the Season 85 Rookie-MVP Angel Canino, Season 85 First Best Middle Blocker Thea Gagate, 2024 SSL National Collegiate Conference MVP and Best Opposite Spiker Shevanna Laput, Alleiah Malaluan, Maicah Larroza, Julia Coronel, Baby Jyne Soreño, and others, tried to defend the crown and further cement DLSU's dominance in the league but they were defeated in the eliminations twice by the UST Golden Tigresses.

However, when they played against their collegiate arch rivals, the DLSU Lady Spikers again showed dominance against the Ateneo Blue Eagles to extend their wins against the Katipunan-based squad 14-0 since the Game 1 of the Finals of Season 79.

During the playoff for the twice-to-beat advantage, the DLSU Lady Spikers once again found themselves in the losing end when they were defeated by the UST Golden Tigresses, 3-1.

In the Final Four battle, they were able to extend the match to 5 sets against the twice-to-beat UST Golden Tigresses but eventually succumb to their fierce rivals from España and were unable to defend the crown.

Thea Gagate, the 3x UAAP Best Middle Blocker awardee, led the list of graduating DLSU Lady Spikers, together with the seniors Julia Coronel, Maicah Larroza, and Jhay-ar Levina.