2CTT, 2DN9909383945ENSG00000276726ENSG00000103423ENSMUSG00000004069Q96EY1Q53G26Q99M87NM_005147NM_001135110NM_001286516NM_001135112NM_023646NP_001128582NP_001273445NP_005138NP_005138.3NP_001128584NP_076135DnaJ homolog subfamily A member 3, mitochondrial, also known as Tumorous imaginal disc 1 (TID1), is a protein that in humans is encoded by the DNAJA3 gene on chromosome 16.

[7][9][11][12] As a member of the DNAJ/Hsp40 protein family, DNAJA3 contains a conserved DnaJ domain, which includes an HPD motif that interacts with Hsp70 to perform its cochaperone function.

[6][7][8][9][10] The DnaJ domain is composed of tetrahelical regions containing a tripeptide of histidine, proline and aspartic acid situated between two helices.

DNAJA3 homogenizes membrane potential through regulation of complex I aggregation, though the mechanism for maintaining mtDNA remains unknown.

[7] These functions then allow DNAJA3 to mediate mitochondrial fission through DRP1 and, by extension, cellular processes such as cell movement, growth, proliferation, differentiation, senescence, and apoptosis.