The studio originally worked on miscellaneous projects for other companies, including commercials and corporate videos, before branching out to television and film animation.

[1][2] In their spare time during the early 1990s, Davis and Alcorn produced crude animated projects and would enter them in touring festivals, which helped their company rise to prominence.

[4][2][8] Other short projects included the pirate-themed Weird Beard,[2][9][10] and The Adventures of Nippleless Nippleby, about a cherub who has no nipples.

[2] By 1994, DNA had branched out to 3D animation after a corporate client, Mary Kay, requested a conference presentation that would feature dancing bottles of suntan lotion.

[12][13] In 1995, filmmaker Steve Oedekerk heard about a proof of concept video of the character, shown by DNA at an awards festival for animated projects.

[1][2][14] After seeing the footage himself, Oderkerk partnered with DNA on two television specials, The O Show and the animated Santa vs. the Snowman, both released in 1997.

[1][2][15] The latter was DNA's biggest project to date, requiring long hours to be finished in time for its Christmas airing.

"[2] That year, the studio increased its staff from 17 to 30 workers to deal with the new projects,[2] which included another animated holiday special titled Olive, the Other Reindeer.

[1][2] Plans for the TV project and an animated feature film were greenlit by Nickelodeon in 1999, with the character name changed to Jimmy Neutron.

[23] The studio then started work on the television series, The Adventures of Jimmy Neutron, Boy Genius,[24][25] which aired on Nickelodeon from July 20, 2002 to November 25, 2006.