[5] Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region.

This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat.

It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development.

[7] In addition, a polymorphism (SNP) in DYRK1A was found to be associated with HIV-1 replication in monocyte-derived macrophages, as well as with slower progression to AIDS in two independent cohorts of HIV-1-infected individuals.

[10] Rosie, the protagonist of BBC sitcom There She Goes, has the DYRK1A gene, as revealed in the show's final episode.