Bufadienolides are steroids and cardiac glycoside aglycones (meaning that they bind with carbohydrates to form cardiac glycosides) that are similar to cardenolides, differing only in the structure of the C-17 substituent on the D ring.

This chemical has been found to be toxic in experiments on mice.

[1][2] It is one of five bufadienolides that have been isolated from Kalanchoe daigremontiana.

Crassulaceans are one of the prime sources of bufadienolide cardiac glycosides (including daigremontianin) responsible for an estimated 33% of cattle mortalities related to plant poisoning in South Africa.

Crassulacean bufadienolides cause cardiac poisoning, but repeated small doses cause a condition called cotyledonosis,[3] an intoxication affecting nervous and muscular systems of small animals, particularly, sheep in the Karoo area of South Africa.