Blind rose through the youth ranks at Ajax, becoming a regular after a loan to Groningen, and won four consecutive Eredivisie titles with the club.

In the summer of 2018, Blind returned to Ajax, where he won his fifth Eredivisie title and a first-ever KNVB Cup in his first season back at the club.

A full Netherlands international from 2013 to 2024, Blind earned over 100 caps, and was a member of the Dutch squad that finished third at the 2014 FIFA World Cup.

Blind made an immediate impact when he forced a corner kick through a Volendam defender, from which Jan Vertonghen scored the winning goal for Ajax.

[7] Under newly appointed manager Frank de Boer, Blind would be given more and more trust and playing time, earning him the place as the first-choice left back with a permanent starting position during the 2012–13 season.

[12] On 23 April 2013, it was announced by Marc Overmars that Ajax and Blind had reached an agreement to extend his contract for three years, binding him to the club until the summer of 2016.

[citation needed] During the 2013–14 season, De Boer moved Blind back to his natural defensive central midfielder position and was named Dutch Footballer of the Year as Ajax won a fourth consecutive league title.

[16] Blind made his debut 13 days after his signing, playing the full 90 minutes as United beat Queens Park Rangers 4–0 at Old Trafford for their first victory of the season.

[18] On 16 November, Blind sustained a knee ligament injury in the Netherlands' UEFA Euro 2016 qualifier against Latvia[19] which kept him out of the Manchester United team for the remainder of 2014.

[22] He began the 2016–17 Premier League season as first-choice centre back alongside Chris Smalling, however, lost his place in the team following a return to form of Phil Jones and Marcos Rojo.

[25][26] On 16 December 2018, Blind scored his first senior hat-trick, in an 8–0 league win over De Graafschap at home, whilst playing as a centre back.

Having had previous call-ups, Blind made his debut for the Netherlands senior team on 6 February 2013, in the starting left-back position, against Italy in a friendly at the Amsterdam Arena.

He was a starter at left wing back for the team's opening match against Spain, assisting goals for Robin van Persie and Arjen Robben, as the Oranje won 5–1.

[44][45] After initially being cut from the Netherlands' squad for the 2023 UEFA Nations League Finals, Blind was recalled as a replacement for the injured Matthijs de Ligt on 12 June 2023.