Wycoff's previous book, the short story collection O Street, was nominated for a Lambda Literary Award for Lesbian Debut Fiction in 2007.

[1] Amy Rotolo's announcement to her family that she is a lesbian sets off a series of events which threaten to unravel the tight knit members of Pastor Lou Bianchi's fundamentalist Christian church in Riverview, New Jersey.

"[3][4] Deb Olin Unferth called it "riveting" and "addictive", adding that "this dazzling book will win you over fast and then splinter your soul.

"[3][4] Cris Mazza wrote: Damascus House develops rich pathos for those who choose to cut ties as well as those who remain, while delicately maintaining a focus on the human drama, with neither an indictment nor endorsement of religion itself, except to observe how contemporary people use, abuse, rely on, form identity with, can be disillusioned or buoyed by a man-made institution.

"[3][4] Foreword Reviews described Damascus House as "a knockout as a late-blooming bildungsroman", and called it "an astounding, crisp, and un-ironic portrait of one religious community’s unraveling".