Wayans Jr. also surprised audiences when he garnered a standing ovation during his debut appearance on Def Comedy Jam.

From April 2011 to May 2013, Wayans starred as Brad Williams, one of the lead characters in the ABC comedy series Happy Endings, alongside Eliza Coupe, Elisha Cuthbert, Zachary Knighton, Adam Pally, and Casey Wilson.

On May 16, 2011, the Fox Network announced that it had picked up the Zooey Deschanel anchored comedy New Girl, which featured Wayans in the supporting role of Coach.

[6] Instead, starting with the second episode, Wayans' character was substituted with Lamorne Morris,[7] playing the role of Winston, a former roommate who had been pursuing a professional basketball career in Latvia.

In 2025 he is starring alongside his father Damon Wayans Sr. on a show poppa's house loosely inspired by their actual life.