She is the sister of Keenen Ivory, Damon Sr., Marlon, Shawn, and Nadia Wayans and aunt of Damien Dante among others.

Wayans was a part of the cast at its outset in 1990,[14] where she did celebrity impressions of Naomi Campbell,[15] Whitney Houston, Vanessa Williams[16] and Oprah Winfrey.

[17] Regarding original characters, one reviewer opined she was "hysterical" as Mrs. Brooks[18] and another claimed Wayans played Benita Butrell "to perfection.

"[19] She left the series along with her brothers Keenen Ivory and Damon in 1993, after a dispute between Fox and the three Wayanses regarding reruns and syndication.

[22] She appeared as Mrs. Johnson in Don't Be a Menace to South Central While Drinking Your Juice in the Hood (1996),[23] and had a starring role in the art film Talking About Sex.

[27] In 2008, she co wrote a series of children's books with her husband Kevin Knotts, titled Amy Hodgepodge, about a multiracial girl adjusting to life in public school after years of homeschooling.