[1][2] Iassogna was the third base umpire when Detroit Tigers pitcher Justin Verlander threw a no-hitter at Comerica Park against the Milwaukee Brewers on June 12, 2007.

Both Fielder and Tigers manager Jim Leyland argued, but video replays showed that the correct call was made.

[6][7] On May 15, 2016, Iassogna was the home plate umpire when the Toronto Blue Jays visited the Texas Rangers.

Iassogna and first base umpire Dale Scott ejected Bautista, Odor, Blue Jays third baseman Josh Donaldson, Rangers bench coach Steve Buechele, Blue Jays pitcher Jesse Chavez, and bench coach/acting manager DeMarlo Hale.

Hale was acting as the Blue Jays’ manager due to the ejection of John Gibbons (along with first base coach Tim Leiper) earlier in the game.

[10] Having considered firefighting before becoming an umpire, Iassogna volunteers with the Chicago Fire Department's "Bucks for the Burn Camp," Team Kevin brain tumor research and the New York Fire Department's "Lil Bravest" charities; he also plays the Great Highland Bagpipes.