On September 12, 2009, at Michigan State, LeFevour passed Byron Leftwich to take over as the MAC all-time leader in total offense in a career.
Chicago signed veteran Todd Collins to be the third-string quarterback, and waived LeFevour after the 2010 preseason in hopes of placing him on the practice squad.
[15] LeFevour was claimed off waivers by the Cincinnati Bengals the next day, and spent the 2010 season as the third-string quarterback, but did not see any action.
[17] On June 4, 2012, the Hamilton Tiger-Cats of the Canadian Football League signed LeFevour as a free agent.
[18] LeFevour dressed for all 18 games of the 2012 CFL season with the Ticats as the third-string quarterback, but did not receive any playing time.
Prior to the 2013 CFL season, LeFevour competed against Brian Brohm and Jeremiah Masoli, both from the now-inactive United Football League, for the backup quarterback position.
He played a prominent role in both preseason games, completing 17 of 29 passing attempts for 229 yards, 1 touchdown and 0 interceptions, and secured the second-string position (Masoli took third string and Brohm was placed on injured reserve).
After starter Henry Burris had a mediocre start of the season, LeFevour saw his first CFL regular-season game action in week 6 of the 2013 season, playing spot duty mostly in short-yardage situations where Burris was having particular difficulty and LeFevour's running and scrambling skills were put to use.
LeFevour began the 2014 season demoted to third on the depth chart; although Burris left for the Ottawa Redblacks and Brohm was traded to the Winnipeg Blue Bombers, the team signed Zach Collaros during the offseason as Burris's replacement and promoted Masoli to second string.
On July 26, 2014, LeFevour made his first CFL start, against the Ottawa Redblacks at a game played at Ron Joyce Stadium.
[24] On August 8, 2016, LeFevour signed a practice roster agreement with the Toronto Argonauts of the Canadian Football League.
He was the starting quarterback for the Bombers for their final regular season game against the Calgary Stampeders, completing 13 of his 17 pass attempts for 91 yards in the 23–5 victory.