LeFors was selected by the Carolina Panthers in the fourth round (121st overall pick) of the 2005 NFL draft out of the University of Louisville.

LeFors conducted workouts for the Tampa Bay Buccaneers, Minnesota Vikings, Seattle Seahawks, Buffalo Bills, Detroit Lions, Oakland Raiders, and Denver Broncos but was not offered a contract.

According to head coach Danny Maciocia, LeFors shares the job as 2nd string quarterback on the Eskimo depth chart for the 2008 campaign with Jason Maas.

On January 21, 2009, LeFors was traded to the Winnipeg Blue Bombers for a second-round pick in the 2009 CFL draft and a conditional selection in 2010.

LeFors returned to Louisville and took a position with the U of L athletic department, also serving as a color analyst for the U of L radio network during the 2010 football season.

In May 2011, he was named the new head football coach at Christian Academy of Louisville.,[4][5] He has led the Centurions to the Kentucky Class AA title in 2016[6] and 2018.