Galifianakis's other films include Due Date (2010), It's Kind of a Funny Story (2010), The Campaign (2012) and Birdman or (The Unexpected Virtue of Ignorance) (2014).

'"[16] Galifianakis co-starred in the film Out Cold, and had small roles in Corky Romano, Below, Bubble Boy, Heartbreakers, Into the Wild, Super High Me, Little Fish Strange Pond and Largo.

It included a stand-up routine, a segment with a piano, and a cappella group The Night Owls (introduced as his "12 ex-girlfriends") singing "Eternal Flame" by The Bangles while he made jokes.

It featured many of his friends and regular performers from the Los Angeles comedy and music venue Largo where he appeared frequently during this time period.

A year later, Kanye West employed Galifianakis and indie rock musician Will Oldham for similar purposes in the second version of the video for his song "Can't Tell Me Nothing".

In June 2006, Galifianakis released the single "Come On and Get It (Up in 'Dem Guts)",[17] a comedic hip-hop dance song which features Apple's vocals.

Much of the tour was taped and has been featured in both a short-lived TV series on Comedy Central and a full-length film that has appeared at SXSW and on Showtime.

That same year, Galifianakis appeared in a web video series of advertisements for Absolut vodka, along with Tim Heidecker and Eric Wareheim, creating a parody of the Golden Girls in which one has a deep anger issue, breaking the fourth wall in exasperation and outright violence on the set.

[citation needed] His 2006 stand-up concert film Zach Galifianakis Live at the Purple Onion was one of the first original programs from Netflix.

He has interviewed Jimmy Kimmel,[21] Michael Cera, Jon Hamm,[22] Natalie Portman,[23] Charlize Theron, Bradley Cooper, Carrot Top, Conan O'Brien, Andy Richter, Andy Dick, Ben Stiller, Steve Carell, Sean Penn, Bruce Willis, Tila Tequila, Jennifer Aniston, Will Ferrell, Samuel L. Jackson, Tobey Maguire, Arcade Fire, Justin Bieber, Brie Larson, David Letterman, former President Barack Obama, Hillary Clinton, Brad Pitt, and Keanu Reeves.

[26] Galifianakis played Alan Garner in the hit comedy The Hangover and earned the MTV Movie Award for the Best Comedic Performance.

In 2011, he reprised his role for The Hangover Part II, which was set in Thailand,[32] and voiced Humpty Dumpty in Puss in Boots.

[33] He received critical praise for his performance in the 2014 film Birdman or (The Unexpected Virtue of Ignorance), in which he starred with Michael Keaton, Emma Stone, and Edward Norton.

[37] In August 2012, Zach Galifianakis married Canadian charity worker Quinn Lundberg at the UBC Farm in Vancouver.