Formed by students of St. Louis University High School in 1988, MU330 played a self-described brand of music called "psycho ska", high energy ska punk marked by manic performances and humorous, often strange lyricism.

Since 1997, the band's musical direction has changed towards a more melodic and lyric-driven ska/indie rock sound, a combination that has been described as "Weezer meets The Specials".

[1] Dan Potthast (guitar/vocals), Ted Moll (drums), Chris Diebold (bass guitar), and Robert Bell (trombone) have remained with MU330 since the band's inception, and the trombonist Gerry Lundquist has been a member for over two decades.

[2] The original members met in St. Louis University High School music class 330, hence the band's name.

[3] Potthast has released solo work and has also started a second band, The Stitch Up, with the former Slow Gherkin frontman, James Rickman.