The show is about Dan, a jobless misanthrope with a soft spot for his cat, Mr. Mumbles, caught in odd misfortunes and unable to provide income for himself.

Accompanying him is his better-off friend Chris, who lives in a comfortable home and has a steady income (he even reluctantly pays for the little or big expenses that Dan needs).

Both their friendship, stemming from a bad experience at summer camp, through high school these two, along with Chris' wife Elise, go after the things that make society even more unbearable than it already is.

Carlos Alazraqui portrays a balloon cult member in "New Mexico", both a surfer and a lifeguard in "The Beach", Maurice in "The Fancy Restaurant", Magnifico the Magnificent in "The Magician", and Flynn Goodhill in "Parents", among others.

Other guest stars include Clancy Brown, Mark Hamill, Tom Kenny, Bill Kopp, Kevin McDonald, John C. McGinley, Daran Norris, Kurtwood Smith, Cree Summer, Harland Williams, and Henry Winkler for various parts.

Dan is forced to take a course in anger management to control his destructive instincts, and finds a kindred spirit in the mild-mannered, but incredibly unstable class instructor named Amber.

When Dan is forced to get a temp job to pay his rent, his aggressive behavior helps him climb the corporate ladder.

Mandel's original idea was for the show to be a live-action sitcom, but new possibilities opened up once they started development for an animated series.

[6] The design for the characters was handled by a team of artists led by supervising director Matt Danner with some involvement from Mandel and Pearson.

His statement read: Christian Paredes, James Jones and Larry Reaper, among others, have been kind enough to ask about Dan Vs., the animated series I've been doing for the last few seasons on The Hub.

I loved everyone I worked with, the company was great, the network was supportive and, of course, the fans were rabid and vocal in their enthusiasm.

[7] In March 2012, Starz and Anchor Bay Entertainment have licensed the home video rights to the series in the United States and Canada.

[9][10] As of 2025, all 53 episodes of the series are currently available for free on Tubi and The Roku Channel in the United States, as well as Crave via its Starz subscription in Canada.