The series is based on the Littlest Pet Shop and Blythe toylines by Hasbro and was broadcast on Discovery Family from November 10, 2012 to June 4, 2016.

Hasbro released a new line of Littlest Pet Shop toys designed to more closely resemble the characters on the series.

Her adventure begins when she discovers that she alone can miraculously understand and talk to the pets that regularly stay at the shop, in addition to most other animals on the planet.

The pets who reside in the day camp of the shop are Pepper Clark, a wisecracking striped skunk who is passionate about comedy; Minka Mark, a bouncy spider monkey with a love for painting and visual arts; Penny Ling, a sensitive giant panda interested in rhythmic gymnastics; Russell Ferguson, a hedgehog who is often the self-appointed leader of his animal bunkmates; Sunil Nevla, an Indian mongoose and hopeful magician; Vinnie Terrio, a clumsy gecko obsessed with dancing; and Zoe Trent, a diva-like Cavalier King Charles Spaniel with a talent for singing.

Hasbro sold Littlest Pet Shop toys under the name of this division until they closed down Kenner's original Cincinnati headquarters in 2000.

A prior incarnation of such a character is the protagonist of Littlest Pet Shop Presents, an unrelated animated miniseries produced by Cosmic Toast Studios and released by Hasbro exclusively on the internet.

[7] Julie McNally-Cahill and Tim Cahill, the creators of Cartoon Network's My Gym Partner's a Monkey, developed Littlest Pet Shop upon joining Hasbro Studios in September 2011.

[8] The show was announced in March 2011,[9] based on Hasbro's 2010 introduction of the Blythe Loves Littlest Pet Shop toy line.

Hasbro originally felt discouraged over having the show set at the pet store, finding the exchange of animals they thought would come from that disconcerting.

The Cahills saw the studio's definition of such stores as antiquated, convincing them that most modern locations provide grooming and daycare services as opposed to merely selling pets.

While the show is aimed at a demographic of young girls,[b] Julie explain that she and the writers attempt to cater to boys of the same age and parent viewers simultaneously.

Adapting these boards to limited animation, studio DHX Media handles the designs, poses, and keyframes of movement for each character appearing in a given scene for an episode, as well as background art.

[8] Supervising director Dallas Parker similarly explained that the variety of assets created for each episode challenged the process of Flash animation in reusing movements.

Factory has acquired North American distribution rights for programs broadcast by The Hub, releasing several DVD sets for Littlest Pet Shop.

[21] Clear Vision, a distributor located in the United Kingdom, obtained the rights for its first two seasons for most of European regions and the Middle East.

[27] Hasbro rebooted their toy line in accordance with the show; newer collections features customizable sets for fans to "create, decorate and personalize their own scenes" inspired by episodes.

She praised Blythe as a model of "integrity, self-confidence, loyalty, and creativity" but found fault with product placement and the "run-of-the-mill" pet characters.

[37] While in the United Kingdom the game was subject of controversy concerning its incorporation of in-app purchases, the Advertising Standards Authority deemed it acceptable.

[39] An adaptation made up of five issues, released from May 7 to September 17, 2014,[40] was written by Georgia Ball and Matt Anderson and illustrated by Nico Peña and Antonio Campo.