[2] As a redshirt junior in 2016, he played cornerback, tying the team lead in interceptions with two, finishing fourth in total tackles with 60 and second in pass breakups with seven.

[7] On September 16, 2018, he scored his first NFL touchdown on a fake punt against the Houston Texans by hauling in a 66-yard reception from Kevin Byard.

Cruikshank was named American Football Conference Special Teams Player of the Week for his performance in the 20–17 victory.

On December 1, 2019, vs the Indianapolis Colts at Lucas Oil Stadium, Cruikshank blocked a fourth-quarter field goal attempt by Adam Vinatieri, which backup cornerback Tye Smith scooped up and took 63 yards for a go-ahead touchdown that sent Tennessee on its way to a 31–17 victory.

“Everybody takes advantage of their opportunities and I rose to the occasion (Sunday) and made the best of it.”[10] On September 6, 2020, Cruikshank was placed on injured reserve.

[12] In week 7 against the Pittsburgh Steelers, Cruikshank recorded his first career interception off a pass thrown by Ben Roethlisberger during the 27–24 loss.